Explain the factor V Leiden genetic mutation and blood clot risk

My mother has celiac disease and recently had two large blood clots removed from her legs. She does have mobility issues as well. It would be helpful to know if celiac disease increases the risk of DVT as other members of the family have been diagnosed celiac as well.

My daughter had DVT, it was discovered because her leg became quite enlarged. Upon further testing she was diagnosed with Lupus. We treated the DVT with daily injections of Lovenox for almost a year. Unfortunatley, shortly before her 22 birthday, and about three weeks before a doctors appoint intended to x-ray the area of the clot, she died. The medical examiner and I both agreed that she most likely died from a piece of the clot traveling and lodging in either her brain or lungs. Although, we followed protocol for the treatment of her DVT, I will always regret not following up on it sooner and looking at it to see if it had shrunk and showed signs of improvement, using the additonal treatment plans available may have saved her life.

Nice, thanks for share! lower leg pain
causes

I am a doctor, an adult cardiologist.
My understanding is that celiac disease is associated with DVT/blood clots. You lose clotting factors through your stool as you fail to absorb things with celiac.

I have Factor V Leiden and also have had 3 DVTs invovling 3 deep veins each time. I have clotted while theraputic on Coumadin. It's important to everyone to know the signs of DVTs and to get it checked out ASAP if you recognize any symptoms. It's also important for women who are on birth control pills and/or hormone replacement therapy to be cognizant of the possibility of an increased incidence of DVTs while on these medications.

My daughtewr ,a fit and healthy 21 yr old was complainnig of pains in her leg but the hospital put it down to muscular pain as she is a black belt in kick boxing.Four weeks after she ahd attended the hospital last october she woke in middle of night screaming that she couldnt breath .It took the hospital over 12 hours to realise what was wrong with her and were going to send her home.She had a blood clot on each lung which had traveled from the leg.A young doctor on the ward suggested that she had the test for factor v leiden and they found out she has it.I thank god she was not sent home because she is so fit the oxgen levels in her blood were good it was only for that one doctor who sent her for a scan.They have said she is a carrier of it and i have been tested iam to,i dont really know what carrier means but i know it has to be taken seriously.looking back on family history my nan died of a blood clot after a operation ,this is a hidden gene and usually only is found when something serious happens,i have wrote this and ask anyone with symptoms of a blood clot to go to the hospital and be persistant as i will in future you are sometimes talking of life or death here.Take care everyone.

i was a dancer for years always very active. at 45 i developed a DVT in my calf after having torn the calf muscle in 3 places playing tennnis. after this i developed another DVT and had other signs of circulatory issues showing up. for about 2 yrs before this i had circulation issues show up also. i was diagnosed with factor v leiden. only one side of family apparently had the gene. i am now under eval by a vascular surgeon due to developing a clot out of the blue while sitting at my desk at work about 3 wks ago. It is a scary disorder. i have been on 325 mg aspirin for the last 2 yrs but it does not seem to be working.

Blood clots can lead to many health complicatons including stroke and are more common among inactive and/or obese individuals.

Blood clots are life threatening however exercise can help prevent their formation and assist in dissoving of existing clots. This fact was discovered and presented to the American Heart association in 2003 by the University of Colorado Health Sciences Center.

The study found that levels of an essential blood clot dissolver known as tissue type plaminogen activator (t-PA) are greatly diminished in overweight men (by as much as 30%). This reduced protection in the blood stream leads eventually to problems with blood clots.

Walking for a period of three months for a mere 45 minutes a day, five days a week however increased the amount of t-PA in the obese participants blood by as much as 50%. The study showed that after this walking regimine the obese subjects had similar levels of t-PA in their blood to that of lean participants in the study. Read more at http://www.trekdesk.com/walk/Blood_Clot.html

I have Factor V Leiden and also had DVT's in several locations of my body. I had a stroke and none of the family was aware that any of carried this mutation until June 17,2009.
I will definatley watch for things that I did not pay attention to before. What I thought was a spider bit on my leg that was painful and I couldn't walk had in the ER about a month later and that was after seeing a doctor for it.

At 52, I learned that I have the V Leiden genetic "expression" after my 26 year old triathelete daughter developed a DVT. She was on the pill, but didn't know she had the Leiden defect until she developed a DVT after a long bike ride. Apparently, some of her doctors are advising her against pregnancy, saying it would put her at too high a risk for another DVT, now that it is known she has Leiden. This bothers me because I had two full-term babies before I knew I had this defect, and I didn't have any blood clots. Maybe I was lucky. However, I did develop a superficial vein thrombosis after a 3 hour flight when I was 49 years old. I think it is almost criminal that my vascular surgeon at the time (3 years ago) did not have me tested for Leiden, as I am very athletic and not overweight, don't smoke, etc – I was very low risk for blood clots. If he had recommended that I get tested, I could have passed this info on to my daughter, had her tested, and she could've avoided the scary DVT episode by discontinuing the pill.

It is curious that some people with Leiden sail through years without problems, and others have repeated DVTs. I suppose it boils down to other risk factors, like diet, weight, hormone therapy, smoking, etc. It is rotten to be carrying around this propensity for hypercoagulability, but I guess there are worse things to live with. It is nice to read other posts and discover how others are dealing with this.

I was diagnosed with Factor V Leiden 5 minutes before being discharged from the hospital after a week long stay for 3 seizures. At the beginning of the week I could not move my left arm and my mother took me to the emergency room just in case I had a stroke. I did not. They tested my spinal fluid in case I had a brain aneurism. Nothing was found. The next day we went to my family doctor for a check up from the E.R. The doctor could not find anything wrong, and I grew very fatiqued so my mom helped me into the backseat of our car. Two days later I woke up in the emergency room again. Apparantly I seized in the back of our car. And again in the ambulance. And again upon arrival to the e.r. I had a large blood clot on the right side of my brain. I am 19 years old. I was hooked up to a cocktail of drugs, to stop the seizures, to thin the blood, and to control my nausea. After a week long stay they decided that since I could walk on my own I could be discharged and continue with the medication. Five minutes before leaving, the head neurologist told my family I had the factor v leiden disorder and that my birth control pills triggered the blood clot. I had been taking birth control since I was 11 because it was believed I had endometriosis. Factor v leiden explains alot of the pain I grew up with. I can no longer take birth control. And I feel nothing but heartfelt and sincere appreciation for all the nurses and techs who had to put up with a 19 year old little girl crying every morning at 5 am for a week when they would come wake me up and dump a pile of 8-10 different viles they had to fill with my blood.

My biggest fear is that another young girl who believes she is protected by birth control will experience clotting issues and not discover them until she is strapped to an i.v. being pumped with meds. I feel insanely lucky that all my pains are explained and that I was not driving when I first began the seizures. I feel that many unexplained deaths in my family have possibly been solved. Though I am also very angry that because of my seizures, I cannot attend fall semester of college, or even drive for 6 months, or be active since bruising could cause internal bleeding. I am also angry that if I do decide to have children, I have to plan the whole thing. The magic of surprise cannot happen thanks to the blood clotting.

Wow, this is very interesting and kinda scary honestly. I have Celiac Disease and I did not know that people with CD were more prone to develop DVT. I am glad I read this though, to know what to watch out for. I am also on Birth Control, I only get pain in my calves from time to time but I also tore my right calf muscle a few years back so it could just be that acting up from time to time since it did not heal right. Very informative post!

- Jessika : Celiac Speaks – Symptoms, Recipes, Restaurants and Daily Life

This is my second posting. I had a lousy thing happen related to Leiden, but just an annoyance compared to many of the anecdotes above. But, this is something anyone with Leiden should watch out for.

I was getting an MRI with contrast about 10 days ago. I was well-hydrated, but the tech could not stick the vein in my arm crease. My hand veins are very prominent, so he stuck my hand and injected the gadolinium (contrast dye) into my hand. Several hours later, tenderness in my forearm. Worse the next day and the next. It was the weekend, so I didn't get medical attention until 3.5 days after the injection. The urgent care doc said it was phlebitis, but I now know that it had already progressed to SVT, as I've had SVT in my leg and I recognize the feeling. Phlebitis should resolve with elevation, high does aspirin and hot compress, but this did not resolve. Had I known to do these things in the first few days, maybe I could've avoided the SVTs.

Moral of this story is this: If you have Leiden or some other clotting disorder, be wary of technicians injecting you with foreign substances, especially in your hand. Several nurses I have talked with said gad should not be injected into a hand vein – too small, which increases likelihood of complication. I know my Leiden defect played a part, but the tech and referring doc should've been on top of this. Inexperienced tech – quite young.

If any of you have had treatment for endometrial polyps, plz let me know about it. I have Leiden and my doc is recommending uterine fibroid embolization as treatment. However, I think I am at fairly high risk for unwanted blood clots in other arteries, due to the Leiden. I am considering asking for hysteroscopic resection, or just a vaginal hysterctomy. I don't think my doc has ever had a Leiden patient before who needs treatment for endometrial polyps. Any feedback would be appreciated.

Jackie

`here is one for you all I have AT3 with a factor v leiden and now they think that I all so have lupus on top of it I have been on meds now for years doing home PTs and doing ok but for the last 4 years i have gone down hill i am 35 and most days i feel like i am 65 and on top of that I have Osteoarthritis what am i to do now